DNA

Can DNA really explain the ancient origins of populations? of individuals? Does DNA prove that the “Anglos” and related Western Peoples did not originate from Israel? What does DNA really tell us? How reliable is it? Are Palestinians related to Jews more than West Europeans are?

http://www.britam.org/Questions/QuesDNA.html#10

R1b1b2 is the most common haplogroup in western Europe, where its branches are clustered in various national populations. R1b1b2a1a2b is characteristic of the Basque, while R1b1b2a1a2f2 reaches its peak in Ireland and R1b1b2a1a1 is most commonly found on the fringes of the North Sea.

Confined in Europe to Iberia and southern France during the Ice Age, R1b spread rapidly in the wake of the retreating glaciers. Today it is the predominant Y-chromosome haplogroup from Spain in the south to Britain, the Netherlands and Germany in northern Europe. Certain branches are also found, albeit rarely, in Asia and Africa.

K split off the more ancient haplogroup U8 about 35,000 years ago. Since then, haplogroup K has been involved in migrations from the Near East into Europe, most notably the founding and expansion of Ashkenazi Jewish populations.

The Definition of a Typical Rare Blood Type

As an example of the difficulties of rare Blood, from the perspective of an actual person having a rare Blood type, following here is, stated in the most simple of terms practical, a typical rare Blood type (yours and mine is likely simply O+):

O Rh negative: D- C-E-c+e+, M+S-, Le(a-), K-, Fy(a+b-), Jk(a+b-) CMV-

This means that the individual is negative in the type A and B, so therefore Blood type O. There is no sign of the Rh factor. Then comes the list of stuff that hardly anyone knows about, except Blood researchers:

does not have the D factor
does not have the C factor
does not have the E factor
does have the c factor
does have the e factor
does have the M factor
does not have the S factor
does not have the Le(a) factor
does not have the K factor
does have the Fy(a) factor
does not have the Fy(b) factor
does have the Jk(a) factor
does not have the Jk(b) factor
Yes, keeping in mind, for a Caucasian individual in North America, that the ‘norm’ is most likely O+, that complex formula, above, is an actual real life example.

Also available is DNA Genealogy and Anthropology Testing – DNA research on full-blooded indigenous populations from around the world has led to the discovery and documentation of genetic markers that are unique to populations, ethnicity and/or deep ancestral migration patterns. The markers having very specific modes of inheritance, and which are relatively unique to specific populations, are used to assess probabilities of ancestral relatedness. Available services include: Ancestral Heritage DNA testing, Native American DNA Verification, Y-Chromosome DNA Testing and mtDNA Sequence Analysis.

The Definition of a Typical Rare Blood Type

http://www.familytreedna.com/products.aspx

http://www.dnaheritage.com/default.asp

http://www.ancestry.ca/

LOS ANGELES – The first modern humans to leave Africa 80,000 years ago encountered Neanderthal settlements in the Middle East and – on at least some occasions – chose to make love instead of war, according to an international team of scientists who have pieced together the genetic code of humanity’s closest relatives.

Traces of that ancient DNA live on in most human beings today, the researchers report in today’s edition of the journal Science.

The finding, which was made by analyzing DNA from Neanderthal bones and comparing it to that of five living humans, appears to resolve a longstanding mystery about the relationship between Neanderthals and Homo sapiens, who coexisted in Europe and western Asia for more than 10,000 years until Neanderthals disappeared about 30,000 years ago.

“We can now say with absolute certainty that we’ve got these Neanderthal genes,” said John Hawks, an evolutionary geneticist at the University of Wisconsin who was not involved in the study. “They’re not #them’ anymore – they’re #us.’”

Svante Paabo, the geneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, who spearheaded the study, said he now sees his ancestors in a new light. His initial research on a different type of DNA that contains far less information had concluded – incorrectly, it turns out – that Neanderthals have no genetic connection to people alive today.

Now, Paabo said, “I would more see them as a form of humans that were a bit more different than people are from each other today.”

Most important, scientists said, knowing the precise structure of the Neanderthal genome will help answer the fundamental biological question: What makes us human?

Neanderthal DNA is 99.7 percent identical to that of people, according to the analysis, which involved dozens of researchers. Something in the remaining 0.3 percent must make us unique.

“It’s not about understanding Neanderthals,” said genome biologist Ed Green, who led the study as a research fellow in Paabo’s lab and is now at the University of California at Santa Cruz. “It’s understanding us.”

By lining up the Neanderthal genome with DNA from humans and chimpanzees, Green and colleagues identified small changes that are unique to humans. Some were in genes involved in energy metabolism, skeletal structure and brain development, including four that are thought to contribute to conditions such as autism, Down syndrome and schizophrenia.

The researchers constructed the Neanderthal genome from three bone fragments found in Croatia’s Vindija Cave. Using a sterile dentistry drill, the scientists removed 400 milligrams of bone powder – an amount equivalent to the size of an aspirin.

Extracting DNA from ancient bones was a dicey proposition.

For starters, 95 percent to 99 percent of the DNA the team found came from microbes that colonized the bones after the Neanderthals died more than 38,000 years ago. To address that problem, the scientists discarded DNA fragments with letter combinations that were especially common in microbes.

In addition, the Neanderthal DNA was badly degraded, which caused sequencing machines to misread some of the chemical letters in the sequence. The researchers developed a computer program to correct those mistakes.

The researchers took special precautions to keep their own DNA out of the Neanderthal samples. Workers wore full-body suits, including masks and gloves. The air pressure inside the lab was kept high so that nothing could blow in accidentally, and the room was irradiated after the researchers went home, Green said.

After four years of work, the team identified 4 billion fragments of Neanderthal DNA and organized them into a draft genome. The sequence is 60 percent complete.

“It is a very poor quality for a human genome, but it is outstanding for a 30,000-year-old extinct hominid,” said Eddy Rubin, who has sequenced samples of Neanderthal DNA at Lawrence Berkeley National Laboratory but was not part of the Science study.

To look for evidence of gene flow between humans and Neanderthals, the researchers sequenced the DNA of five people who now live in southern Africa, western Africa, France, China and Papua New Guinea. Since they didn’t think Neanderthal genes had passed to humans, they expected to find the same degree of difference between the Neanderthal genome and all five people.

Instead, they discovered that the Neanderthal DNA was slightly more similar to the three people living outside of Africa. Even more surprising, the relationship was just as strong for the individuals from China and Papua New Guinea as for the person from France, who lives in the Neanderthals’ old stomping grounds.

The simplest explanation is that a small group of humans met the Neanderthals 50,000 to 80,000 years ago after they left Africa but before they had spread throughout Europe, Asia and beyond. The logical meeting place was the Middle East, which connects northeast Africa to the Eurasian continent.

“The contact must have happened early for the Neanderthals genes to have spread so widely and uniformly,” Henry Harpending, an anthropologist at the University of Utah, who was not involved in the study.

The amount of mixing was small – only 1 percent to 4 percent of the DNA in non-African humans originated in Neanderthals, according to the study. The researchers said none of that DNA is functional; in fact, the particular 1 percent to 4 percent is different in every individual.

Interbreeding may well have continued in Europe, but that would be harder to detect because both populations there were large and any small Neanderthal contribution would be too dilute to see, Paabo said.
Study finds we’re all a little bit Neanderthal