Thalassemia most frequent in O negative women

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It is most frequent in Rh(D) negative women in general.

Female patients have significantly higher frequency of Rh negative, particularly O negative. This study will help in making public health policies.

https://www.researchgate.net/publication/323666035_Distribution_of_ABO_Blood_Groups_and_Rhesus_Factor_In_ss-Thalassemia_Patients_at_Thalassemia_Care_Center_NawabShah_Pakistan

The irregular antibody production for β-thalassemic children with long-term transfusion may have some relevance with Rh factor genotypes and thalassemia genetic mutations. This study possesses a certain significance for effective prevention of RBC alloimmune response of β-thalassemia children and improvement of efficacy and safety of clinical transfasion blood.

https://www.ncbi.nlm.nih.gov/pubmed/26708889

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