{"id":10667,"date":"2021-08-05T20:07:38","date_gmt":"2021-08-05T20:07:38","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=10667"},"modified":"2021-08-05T20:36:20","modified_gmt":"2021-08-05T20:36:20","slug":"how-frequent-is-hemophilia","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/how-frequent-is-hemophilia\/","title":{"rendered":"How frequent is Hemophilia in Rh(D) negative individuals?"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is Hemophilia in Rh(D) negative individuals?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"398\" src=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/hp.jpeg?resize=600%2C398&#038;ssl=1\" alt=\"\" class=\"wp-image-10670\" srcset=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/hp.jpeg?w=600&amp;ssl=1 600w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/hp.jpeg?resize=300%2C199&amp;ssl=1 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n\n\n\n<p>\n\nHaemophilia is&nbsp;<strong>a rare condition that affects the blood&#8217;s ability to clot<\/strong>. It&#8217;s usually inherited. Most people who have it are male. Normally, when you cut yourself, substances in your blood known as clotting factors mix with blood cells called platelets to make your blood sticky and form a clot.<br><\/p>\n\n\n\n<p>\n\nHemophilia occurs in&nbsp;<strong>about 1 of every 5,000 male births<\/strong>.\n\n<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"6081\" height=\"5448\" src=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?fit=640%2C573&amp;ssl=1\" alt=\"\" class=\"wp-image-10672\" srcset=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?w=6081&amp;ssl=1 6081w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?resize=300%2C269&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?resize=768%2C688&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?resize=1024%2C917&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?w=1280&amp;ssl=1 1280w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?w=1920&amp;ssl=1 1920w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n\n<p> Although an individual&#8217;s haemophilia can usually be traced in the ancestry, in about 30% of cases there is no family history of the disorder, and the condition is speculated to be the result of spontaneous&nbsp;mutation&nbsp;in an ancestor. <\/p>\n\n\n\n<p> There are two main types of haemophilia:&nbsp;haemophilia A, which occurs due to low amounts of clotting&nbsp;factor VIII, and&nbsp;haemophilia B, which occurs due to low levels of clotting&nbsp;factor IX. <\/p>\n\n\n\n<p> Haemophilia A affects about 1 in 5,000\u201310,000, while haemophilia B affects about 1 in 40,000, males at birth. As haemophilia A and B are both&nbsp;X-linked recessive disorders, females are rarely severely affected.&nbsp;Some females with a nonfunctional gene on one of the X chromosomes may be mildly symptomatic.&nbsp;Haemophilia C occurs equally in both sexes and is mostly found in&nbsp;Ashkenazi Jews.&nbsp;In the 1800s haemophilia B was common within the royal families of&nbsp;Europe. <\/p>\n\n\n\n<figure class=\"wp-block-embed-wordpress wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"z9tLoPZlz9\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/haemophilia-in-european-royalty\/\">Haemophilia in European Royalty<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Haemophilia in European Royalty&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/haemophilia-in-european-royalty\/embed\/#?secret=0MvmMe1fe1#?secret=z9tLoPZlz9\" data-secret=\"z9tLoPZlz9\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Haemophilia&nbsp;C is a mild form of&nbsp;haemophilia&nbsp;affecting both sexes, due to factor XI deficiency. It predominantly occurs in&nbsp;Ashkenazi&nbsp;Jews with an&nbsp; up to <strong>8% frequency of heterozygosity<\/strong>.  Treatment is usually not necessary, except in relation to&nbsp;operations, leading to many of those having the condition not being aware of it. <br><\/p>\n\n\n\n<p> Studies of&nbsp;gene therapy&nbsp;are in early human trials. <\/p>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is Hemophilia in Rh(D) negative individuals?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is Hemophilia in Rh(D) negative individuals?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Haemophilia is&nbsp;a rare condition that affects the blood&#8217;s ability to clot. It&#8217;s usually inherited. Most people who have it are male. Normally, when you cut yourself, substances in your blood known as clotting factors mix with blood cells called platelets to make your blood sticky and form a clot. Hemophilia occurs in&nbsp;about 1 of every 5,000 male births. Although an individual&#8217;s haemophilia can usually be traced in the ancestry, in about 30% of cases there is no family history of the disorder, and the condition is speculated to be the result of spontaneous&nbsp;mutation&nbsp;in an ancestor. There are two main types of haemophilia:&nbsp;haemophilia A, which occurs due to low amounts of clotting&nbsp;factor VIII, and&nbsp;haemophilia B, which occurs due to low levels <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is Hemophilia in Rh(D) negative individuals?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":10672,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-10667","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/Haemophilia_of_Queen_Victoria_-_family_tree_by_shakko.jpg?fit=6081%2C5448&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-2M3","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/10667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=10667"}],"version-history":[{"count":5,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/10667\/revisions"}],"predecessor-version":[{"id":10679,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/10667\/revisions\/10679"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media\/10672"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=10667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=10667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=10667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}