{"id":10684,"date":"2021-08-08T01:08:34","date_gmt":"2021-08-08T01:08:34","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=10684"},"modified":"2022-01-18T12:41:34","modified_gmt":"2022-01-18T12:41:34","slug":"does-abo-and-rhd-matching-matter-for-platelet-transfusion","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/does-abo-and-rhd-matching-matter-for-platelet-transfusion\/","title":{"rendered":"Does ABO and RhD matching matter for platelet transfusion?"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Does ABO and RhD matching matter for platelet transfusion?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<p>Platelets express ABO antigens and are collected in plasma, which contains ABO antibodies as would be consistent with the donor ABO group. Platelet ABO antigens that are incompatible with recipient ABO antibodies may have accelerated clearance from circulation and result in lower count increments. ABO antibodies that are passively transferred from donor plasma may result in hemolysis of recipient red blood cells. Although platelets do not express Rh antigens, they contain small numbers of intact red blood cells or fragments, which can lead to alloimmunization in the recipient. Alloimmunization to the RhD antigen may occur when platelets obtained from RhD-positive donors are transfused to RhD-negative recipients. All of these compatibility considerations must be balanced against the available supply, which may be limited due to the 5- to 7-day shelf life of platelets. This articles describes considerations for platelet ABO and RhD selection for platelet transfusions, including the impact of major ABO incompatibility on count increments, the risks of hemolysis associated with minor ABO incompatibility, and the risk of RhD alloimmunization when RhD-negative patients receive platelets obtained from RhD-positive donors.<br><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"696\" src=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/source.png?fit=640%2C348&amp;ssl=1\" alt=\"\" class=\"wp-image-10686\" srcset=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/source.png?w=1280&amp;ssl=1 1280w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/source.png?resize=300%2C163&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/source.png?resize=768%2C418&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2021\/08\/source.png?resize=1024%2C557&amp;ssl=1 1024w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><figcaption> <em>Hematology Am Soc Hematol Educ Program<\/em>&nbsp;(2020) 2020 (1): 512\u2013517.<br><br> <\/figcaption><\/figure><\/div>\n\n\n\n<p>Management of the platelet inventory requires careful consideration, given the short shelf life of this product. The supply does not always allow for provision of ABO identical and\/or platelets obtained from RhD-negative donors for RhD-negative patients. Risks of giving non-ABO identical transfusions include decreased count increments and shorter transfusion intervals for major ABO incompatible transfusions and hemolysis of recipient RBCs for minor ABO incompatible transfusions. Provision of platelets obtained from RhD-positive donors for RhD-negative patients may result in alloimmunization to the RhD antigen. This risk appears to be quite low but can be mitigated by the use of RhIg in at-risk populations.<\/p>\n\n\n\n<p>Las plaquetas expresan ant\u00edgenos ABO y se recogen en plasma, que contiene anticuerpos ABO como ser\u00eda coherente con el grupo ABO del donante. Los ant\u00edgenos plaquetarios ABO que son incompatibles con los anticuerpos ABO del receptor pueden tener una eliminaci\u00f3n acelerada de la circulaci\u00f3n y dar como resultado incrementos de recuento m\u00e1s bajos. Los anticuerpos ABO que se transfieren pasivamente del plasma del donante pueden provocar hem\u00f3lisis de los gl\u00f3bulos rojos del receptor. Aunque las plaquetas no expresan ant\u00edgenos Rh, contienen peque\u00f1as cantidades de gl\u00f3bulos rojos intactos o fragmentos, lo que puede provocar aloinmunizaci\u00f3n en el receptor. La aloinmunizaci\u00f3n al ant\u00edgeno RhD puede ocurrir cuando las plaquetas obtenidas de donantes RhD positivos se transfunden a receptores RhD negativos. Todas estas consideraciones de compatibilidad deben equilibrarse con el suministro disponible, que puede estar limitado debido a la vida \u00fatil de 5 a 7 d\u00edas de las plaquetas. Este art\u00edculo describe las consideraciones para la selecci\u00f3n de plaquetas ABO y RhD para transfusiones de plaquetas, incluido el impacto de la incompatibilidad ABO mayor en los incrementos de recuento, los riesgos de hem\u00f3lisis asociados con la incompatibilidad ABO menor y el riesgo de aloinmunizaci\u00f3n RhD cuando los pacientes RhD negativos reciben plaquetas obtenidas de Donantes RhD positivos.<\/p>\n\n\n\n<p> La gesti\u00f3n del inventario de plaquetas requiere una cuidadosa consideraci\u00f3n, dada la corta vida \u00fatil de este producto. El suministro no siempre permite el suministro de plaquetas ABO id\u00e9nticas y\/o obtenidas de donantes RhD negativos para pacientes RhD negativos. Los riesgos de administrar transfusiones no ABO id\u00e9nticas incluyen incrementos de conteo reducidos e intervalos de transfusi\u00f3n m\u00e1s cortos para transfusiones ABO incompatibles mayores y hem\u00f3lisis de los gl\u00f3bulos rojos del receptor para transfusiones ABO incompatibles menores. La provisi\u00f3n de plaquetas obtenidas de donantes RhD positivos para pacientes RhD negativos puede resultar en aloinmunizaci\u00f3n al ant\u00edgeno RhD. Este riesgo parece ser bastante bajo, pero puede mitigarse mediante el uso de RhIg en poblaciones en riesgo.\n\n\n\n\n\n\n\n\n\n\n <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"20\" height=\"20\" src=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2022\/01\/image.png?resize=20%2C20&#038;ssl=1\" alt=\"\" class=\"wp-image-11407\"\/><\/figure>\n\n\n\n<p><br><\/p>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Does ABO and RhD matching matter for platelet transfusion?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Does ABO and RhD matching matter for platelet transfusion?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Platelets express ABO antigens and are collected in plasma, which contains ABO antibodies as would be consistent with the donor ABO group. Platelet ABO antigens that are incompatible with recipient ABO antibodies may have accelerated clearance from circulation and result in lower count increments. ABO antibodies that are passively transferred from donor plasma may result in hemolysis of recipient red blood cells. Although platelets do not express Rh antigens, they contain small numbers of intact red blood cells or fragments, which can lead to alloimmunization in the recipient. Alloimmunization to the RhD antigen may occur when platelets obtained from RhD-positive donors are transfused to RhD-negative recipients. All of these compatibility considerations must be balanced against the available supply, which may <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Does ABO and RhD matching matter for platelet transfusion?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-10684","post","type-post","status-publish","format-standard","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-2Mk","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/10684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=10684"}],"version-history":[{"count":5,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/10684\/revisions"}],"predecessor-version":[{"id":11409,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/10684\/revisions\/11409"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=10684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=10684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=10684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}