{"id":14807,"date":"2022-07-29T13:02:23","date_gmt":"2022-07-29T13:02:23","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=14807"},"modified":"2022-07-29T13:06:42","modified_gmt":"2022-07-29T13:06:42","slug":"hemolytic-disease-of-the-newborn-hdn","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/hemolytic-disease-of-the-newborn-hdn\/","title":{"rendered":"Hemolytic disease of the newborn (HDN)"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Hemolytic disease of the newborn (HDN)\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<p>Here is a short and official explanation:<\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Do you wish to meet another Rh negative?\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/bxnoZ0WsAoY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> A&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Pregnancy\">pregnant<\/a>&nbsp;woman may carry a&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Fetus\">fetus<\/a>&nbsp;with a blood type which is different from her own. Typically, this is an issue if a Rh- mother has a child with a Rh+ father, and the fetus ends up being Rh+ like the father.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_type#cite_note-22\">[22]<\/a><\/sup>&nbsp;In those cases, the mother can make&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Immunoglobulin_G\">IgG<\/a>&nbsp;blood group antibodies. This can happen if some of the fetus&#8217; blood cells pass into the mother&#8217;s blood circulation (e.g. a small fetomaternal&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Bleeding\">hemorrhage<\/a>&nbsp;at the time of childbirth or obstetric intervention), or sometimes after a therapeutic&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_transfusion\">blood transfusion<\/a>. This can cause&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Rh_disease\">Rh disease<\/a>&nbsp;or other forms of&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Hemolytic_disease_of_the_newborn\">hemolytic disease of the newborn<\/a>&nbsp;(HDN) in the current pregnancy and\/or subsequent pregnancies. Sometimes this is lethal for the fetus; in these cases it is called&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Hydrops_fetalis\">hydrops fetalis<\/a>.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_type#cite_note-Letsky2000-23\">[23]<\/a><\/sup>&nbsp;If a pregnant woman is known to have anti-D antibodies, the Rh blood type of a&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Fetus\">fetus<\/a>&nbsp;can be tested by analysis of fetal DNA in maternal plasma to assess the risk to the fetus of Rh disease.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_type#cite_note-24\">[24]<\/a><\/sup>&nbsp;One of the major advances of twentieth century medicine was to prevent this disease by stopping the formation of Anti-D antibodies by D negative mothers with an injectable medication called&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Rho(D)_immune_globulin\">Rho(D) immune globulin<\/a>.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_type#cite_note-25\">[25]<\/a><a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_type#cite_note-26\">[26]<\/a><\/sup>&nbsp;Antibodies associated with some blood groups can cause severe HDN, others can only cause mild HDN and others are not known to cause HDN.<sup><a href=\"https:\/\/en.wikipedia.org\/wiki\/Blood_type#cite_note-Letsky2000-23\">[23]<\/a><\/sup><br><br> <\/p><cite>Source: Wikipedia<\/cite><\/blockquote>\n\n\n\n<p>Here are YOUR precious comments:<\/p>\n\n\n\n<figure class=\"wp-block-embed-wordpress wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"58xXtlzkc2\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/are-you-an-rh-negative-mother-with-an-rh-positive-mother\/\">Are you an Rh negative mother with an Rh positive mother?<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Are you an Rh negative mother with an Rh positive mother?&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/are-you-an-rh-negative-mother-with-an-rh-positive-mother\/embed\/#?secret=zTERBvGx7K#?secret=58xXtlzkc2\" data-secret=\"58xXtlzkc2\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>What have you yourself experienced?<\/p>\n\n\n\n<figure class=\"wp-block-embed-wordpress wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"LTiXD0SCai\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/lessons-learnt-from-many-years-of-experience-using-anti-d-in-humans-for-prevention-of-rhd-immunization-and-haemolytic-disease-of-the-fetus-and-newborn\/\">Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newborn<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newborn&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/lessons-learnt-from-many-years-of-experience-using-anti-d-in-humans-for-prevention-of-rhd-immunization-and-haemolytic-disease-of-the-fetus-and-newborn\/embed\/#?secret=tpjP6aEPyN#?secret=LTiXD0SCai\" data-secret=\"LTiXD0SCai\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Hemolytic disease of the newborn (HDN)\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Hemolytic disease of the newborn (HDN)\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Here is a short and official explanation: A&nbsp;pregnant&nbsp;woman may carry a&nbsp;fetus&nbsp;with a blood type which is different from her own. Typically, this is an issue if a Rh- mother has a child with a Rh+ father, and the fetus ends up being Rh+ like the father.&nbsp;In those cases, the mother can make&nbsp;IgG&nbsp;blood group antibodies. This can happen if some of the fetus&#8217; blood cells pass into the mother&#8217;s blood circulation (e.g. a small fetomaternal&nbsp;hemorrhage&nbsp;at the time of childbirth or obstetric intervention), or sometimes after a therapeutic&nbsp;blood transfusion. This can cause&nbsp;Rh disease&nbsp;or other forms of&nbsp;hemolytic disease of the newborn&nbsp;(HDN) in the current pregnancy and\/or subsequent pregnancies. Sometimes this is lethal for the fetus; in these cases it is called&nbsp;hydrops fetalis.&nbsp;If a <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Hemolytic disease of the newborn (HDN)\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-14807","post","type-post","status-publish","format-standard","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-3QP","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/14807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=14807"}],"version-history":[{"count":4,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/14807\/revisions"}],"predecessor-version":[{"id":14812,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/14807\/revisions\/14812"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=14807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=14807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=14807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}