{"id":2356,"date":"2017-03-08T23:46:21","date_gmt":"2017-03-08T23:46:21","guid":{"rendered":"http:\/\/www.rhesusnegative.net\/staynegative\/?p=2356"},"modified":"2017-03-12T20:05:08","modified_gmt":"2017-03-12T20:05:08","slug":"frequent-cis-ab","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/frequent-cis-ab\/","title":{"rendered":"How frequent is cis-AB?"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is cis-AB?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div><p>Since I have always suspected that this number would be much higher than expected, I am happy to now see proof of that. <\/p>\n<p><a href=\"https:\/\/koreamed.org\/SearchBasic.php?RID=0029KJBT%2F2003.14.1.28&#038;DT=1\" target=\"_blank\"> The frequency of the cis-AB blood type in blood donors in southwestern Korea.  <\/a><\/p>\n<blockquote><p> BACKGROUND: Cis-AB is a rare ABO blood type with an unusual inheritance, on the same chromosome that results from a point mutation. It is relatively common in Korean and Japanese populations. Although more than 100 cases of the cis-AB blood type have been reported, there is no report on the frequency of the cis-AB blood type in Korea. Therefore, we analyzed the frequency of the cis-AB blood type in blood donors in southwestern Korea. METHODS: This study examined <strong>111,842 samples obtained from blood donors<\/strong> recruited at the Gwangju-Chonnam Red Cross Blood Center between July 2002 and Oct 2002. ABO serologic tests were performed on all of the samples and ABO genotyping using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed on peripheral blood DNA samples from 129 cases: 24 A2B3, 81 A2B, 23 A1B3, and 1 A1Bx or el case. RESULTS: <strong>The frequency of the cis-AB blood type was 0.0331%<\/strong>(37\/111,842). Of the <strong>37 cases<\/strong>, 24 cases were the cis-AB\/O genotype with the A2B3 phenotype, 9 cases were the cis-AB\/A genotype with the A2B phenotype, 3 cases were the cis-AB\/B genotype with the A1B3 phenotype, and 1 case was the cis-AB\/A genotype with the A1Bx or el phenotype. In the 129 cases, the cis-AB ratio was 100% (24\/24), 39.1% (9\/23), 3.7% (3\/81), and 100% (1\/1) in the A2B3, A1B3, A2B, and A1Bx or el phenotypes, respectively. CONCLUSIONS: <strong>The frequency of the cis-AB blood type in blood donors in southwestern Korea is about 0.0331%.<\/strong> The most common type of cis-AB was cis-AB\/O with the A2B3 phenotype. In addition, one case of cis-AB\/A with an unusual A1Bx or el phenotype was found.<\/p><\/blockquote>\n<p>So if one of your parents is AB, yet you are O, there is not that much concern.<\/p>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is cis-AB?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is cis-AB?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Since I have always suspected that this number would be much higher than expected, I am happy to now see proof of that. The frequency of the cis-AB blood type in blood donors in southwestern Korea. BACKGROUND: Cis-AB is a rare ABO blood type with an unusual inheritance, on the same chromosome that results from a point mutation. It is relatively common in Korean and Japanese populations. Although more than 100 cases of the cis-AB blood type have been reported, there is no report on the frequency of the cis-AB blood type in Korea. Therefore, we analyzed the frequency of the cis-AB blood type in blood donors in southwestern Korea. METHODS: This study examined 111,842 samples obtained from blood donors <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is cis-AB?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":2368,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":true,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-2356","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2017\/03\/korea-seoul-cis-AB-article.jpg?fit=1024%2C683&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-C0","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/2356","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=2356"}],"version-history":[{"count":2,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/2356\/revisions"}],"predecessor-version":[{"id":2358,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/2356\/revisions\/2358"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media\/2368"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=2356"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=2356"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=2356"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}