{"id":6536,"date":"2020-02-22T16:41:49","date_gmt":"2020-02-22T16:41:49","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=6536"},"modified":"2020-02-22T16:44:06","modified_gmt":"2020-02-22T16:44:06","slug":"how-frequent-is-weak-d","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/how-frequent-is-weak-d\/","title":{"rendered":"How frequent is weak D?"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is weak D?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<figure class=\"wp-block-image\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"360\" src=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/02\/Dphenotypes_DpersonshavefullRHDgeneexpression..jpg?resize=640%2C360&#038;ssl=1\" alt=\"\" class=\"wp-image-6538\" srcset=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/02\/Dphenotypes_DpersonshavefullRHDgeneexpression..jpg?w=960&amp;ssl=1 960w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/02\/Dphenotypes_DpersonshavefullRHDgeneexpression..jpg?resize=300%2C169&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/02\/Dphenotypes_DpersonshavefullRHDgeneexpression..jpg?resize=768%2C432&amp;ssl=1 768w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><figcaption>D\u2013 persons either lack RHD, which encodes for the D antigen, or have a nonfunctional RHD gene. Weak D red cells have the D antigen, but have fewer D antigens per cell than normal Rh positive cells. Red cells lacking components of the D antigen have been referred to in the past as D mosaic or D variant. Current terminology more appropriately describes these red cells as partial D. There is 5 phenotype D (D+, D-, Weak D, partial D, Del)<\/figcaption><\/figure>\n\n\n\n<p>\n\nDefinition: The&nbsp;<strong>weak D<\/strong>&nbsp;phenotype (<strong>D<\/strong><sup>u<\/sup>) is a weakened form of the&nbsp;<strong>D<\/strong>&nbsp;antigen that in routine&nbsp;<strong>D<\/strong>&nbsp;typing will react with some anti-<strong>D<\/strong>&nbsp;but not with others (when an immediate spin or 37\u00b0 incubation is done).&nbsp;<strong>Weak D<\/strong>&nbsp;red cells have the&nbsp;<strong>D<\/strong>&nbsp;antigen, but have fewer&nbsp;<strong>D<\/strong>&nbsp;antigens per cell than normal Rh positive cells.<br><\/p>\n\n\n\n<p> Reduced expression of\u00a0<strong>D<\/strong>\u00a0antigen occurs in an estimated 0.2%\u20131% of Caucasians. Historically, red blood cell antigens that react with anti-<strong>D<\/strong>\u00a0only after extended testing with the indirect antiglobulin test are called\u00a0<strong>weak D<\/strong>.<br> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3320789\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3320789\/<\/a>  <\/p>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is weak D?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is weak D?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Definition: The&nbsp;weak D&nbsp;phenotype (Du) is a weakened form of the&nbsp;D&nbsp;antigen that in routine&nbsp;D&nbsp;typing will react with some anti-D&nbsp;but not with others (when an immediate spin or 37\u00b0 incubation is done).&nbsp;Weak D&nbsp;red cells have the&nbsp;D&nbsp;antigen, but have fewer&nbsp;D&nbsp;antigens per cell than normal Rh positive cells. Reduced expression of\u00a0D\u00a0antigen occurs in an estimated 0.2%\u20131% of Caucasians. Historically, red blood cell antigens that react with anti-D\u00a0only after extended testing with the indirect antiglobulin test are called\u00a0weak D. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3320789\/<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How frequent is weak D?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-6536","post","type-post","status-publish","format-standard","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-1Hq","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/6536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=6536"}],"version-history":[{"count":2,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/6536\/revisions"}],"predecessor-version":[{"id":6539,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/6536\/revisions\/6539"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=6536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=6536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=6536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}