{"id":8491,"date":"2020-08-03T13:47:41","date_gmt":"2020-08-03T13:47:41","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=8491"},"modified":"2020-08-10T12:31:05","modified_gmt":"2020-08-10T12:31:05","slug":"protective-associations-between-rh-negative-blood-groups-and-sars-cov-2-infection-and-death","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/protective-associations-between-rh-negative-blood-groups-and-sars-cov-2-infection-and-death\/","title":{"rendered":"Protective associations between Rh negative blood groups and SARS-CoV-2 infection and death"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Protective associations between Rh negative blood groups and SARS-CoV-2 infection and death\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<p><a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.04.08.20058073v2.full.pdf\">Here is the revised version from July 21st, 2020<\/a> of a study I have recently posted. Thank you to Paul for sharing it in a comment <a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/covid-19-where-are-all-the-rh-negative-patients\/\">here<\/a>. Here are some highlights regarding Rh negative blood and COVID-19 alongside brief comments of mine:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> Using observational data on 7,770 SARS-CoV-2-tested individuals at New York Presbyterian (NYP) hospital, we find evidence of overall association with ABO blood groups and a beneficial association between Rh-negative blood groups and both infection status and death. <\/p><\/blockquote>\n\n\n\n<p>I am happy to see that in this version, the obvious is being focused on which didn&#8217;t happen in the previous one.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> Finally, we show that blood type\u2019s effects are not explained by other risk factors (age, sex, race, ethnicity, hypertension, diabetes mellitus, obesity, and cardiovascular and respiratory diseases). To our knowledge, this is the first report of an independent Rh(D) association with COVID-19. <\/p><\/blockquote>\n\n\n\n<p>This is what I have been waiting for.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> Since there were few AB-negative individuals tested for SARS-CoV-2 infection, we excluded AB-negative from all ABO\/Rh analyses.  <\/p><\/blockquote>\n\n\n\n<p>Also, great move. Sure enough, the initial version prompted some people to assume that AB negatives were immune which couldn&#8217;t be further from the truth.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> While Rh(D) information was not available from the other meta-analysis sites, we found consistent evidence for protective associations between Rh negative blood groups and SARS-CoV-2 infection and death in NYP\/CUIMC data. Negative Rh blood groups are less common, representing only 9% of individuals in our data, and Rh group associations were consistently moderated by adjustment for covariates (Figure 1), suggesting the potential for confounding due to population stratification or selection bias. Further work is needed to better understand the associations between Rh(D) blood groups and COVID-19. <\/p><\/blockquote>\n\n\n\n<p>This particular part I have made several posts and videos about and I am happy they spell it out. Hopefully, more studies will arise and in light of the situation we are in, more efforts will be made to determine the nature of how Rh negatives might enjoy some form of protective associations.<\/p>\n\n\n\n<p><em><strong>Here are more of my personal comments and why this revision is so significant to me:<\/strong><\/em><\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"PROTECTIVE ASSOCIATIONS BETWEEN RH NEGATIVE BLOOD GROUPS AND SARS-COV-2 INFECTION AND DEATH\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/Pao5kq_49j8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>This was my post when the first edition came out:<\/p>\n\n\n\n<figure class=\"wp-block-embed-wordpress wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"R1hU8LQt8r\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/covid-19-deaths-1-out-of-45-rh-and-1-out-of-8-rh-patients-nyp-cuimc\/\">COVID-19 deaths: 1 out of 45 Rh- and 1 out of 8 Rh+ patients  (NYP\/CUIMC)<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;COVID-19 deaths: 1 out of 45 Rh- and 1 out of 8 Rh+ patients  (NYP\/CUIMC)&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/covid-19-deaths-1-out-of-45-rh-and-1-out-of-8-rh-patients-nyp-cuimc\/embed\/#?secret=BF6F77l6KS#?secret=R1hU8LQt8r\" data-secret=\"R1hU8LQt8r\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>This newer study appears to confirm what&#8217;s been indicated about blood type O and Rh negative blood groups:<\/p>\n\n\n\n<figure class=\"wp-block-embed-wordpress wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"zIhoZEruDe\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/new-study-suggests-blood-types-b-ab-and-rh-positives-at-highest-covid-19-risk\/\">New study suggests blood types B, AB and Rh positives at highest COVID-19 risk<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;New study suggests blood types B, AB and Rh positives at highest COVID-19 risk&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/new-study-suggests-blood-types-b-ab-and-rh-positives-at-highest-covid-19-risk\/embed\/#?secret=avJeAR6tI6#?secret=zIhoZEruDe\" data-secret=\"zIhoZEruDe\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Protective associations between Rh negative blood groups and SARS-CoV-2 infection and death\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Protective associations between Rh negative blood groups and SARS-CoV-2 infection and death\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Here is the revised version from July 21st, 2020 of a study I have recently posted. Thank you to Paul for sharing it in a comment here. Here are some highlights regarding Rh negative blood and COVID-19 alongside brief comments of mine: Using observational data on 7,770 SARS-CoV-2-tested individuals at New York Presbyterian (NYP) hospital, we find evidence of overall association with ABO blood groups and a beneficial association between Rh-negative blood groups and both infection status and death. I am happy to see that in this version, the obvious is being focused on which didn&#8217;t happen in the previous one. Finally, we show that blood type\u2019s effects are not explained by other risk factors (age, sex, race, ethnicity, hypertension, <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Protective associations between Rh negative blood groups and SARS-CoV-2 infection and death\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":8495,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-8491","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/08\/youarenotneedingtotalk.jpg?fit=612%2C306&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-2cX","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/8491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=8491"}],"version-history":[{"count":5,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/8491\/revisions"}],"predecessor-version":[{"id":8538,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/8491\/revisions\/8538"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media\/8495"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=8491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=8491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=8491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}