{"id":8655,"date":"2020-09-02T11:58:03","date_gmt":"2020-09-02T11:58:03","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=8655"},"modified":"2020-09-02T15:54:38","modified_gmt":"2020-09-02T15:54:38","slug":"are-rh-negatives-more-likely-to-have-adhd","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/are-rh-negatives-more-likely-to-have-adhd\/","title":{"rendered":"Are rh negatives more likely to have &#8220;ADHD&#8221;?"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Are rh negatives more likely to have &quot;ADHD&quot;?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"391\" src=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/09\/drd4_4-1311x800.jpg?resize=640%2C391&#038;ssl=1\" alt=\"\" class=\"wp-image-8667\" srcset=\"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/09\/drd4_4-1311x800.jpg?resize=1024%2C625&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/09\/drd4_4-1311x800.jpg?resize=300%2C183&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/09\/drd4_4-1311x800.jpg?resize=768%2C469&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/09\/drd4_4-1311x800.jpg?resize=1311%2C800&amp;ssl=1 1311w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/figure><\/div>\n\n\n\n<p>I have previously posted a study on it, but before I post the new one, I would like to first clarify what exactly we may understand or not understand under the term. <\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube aligncenter wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Are rh negatives more likely to have &quot;ADHD&quot;?\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/LanviXFXYmU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>This is not a long video as it would make no sense stretching your attention span over the topic of such. The questions that come to mind are as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>do you tend to tune out quickly or remove yourself from situations that are not for you?<\/li><li>do you have a strong sense regarding what you are and what you are not interested in?<\/li><li>do those talking about low attention span also criticize spending too much time on what you might be interested in? (the accusation of obsessive behavior tends to be not far from the ADHD one)<\/li><li>is faking interest in something painful to you?<\/li><li>do you often think about something else while trying to stay present where you don&#8217;t feel right?<\/li><li>have you ever had your mental health\/stability questioned when someone wasn&#8217;t happy with your lack of enthusiasm over what he\/she spent too much time sharing his\/her interest in?<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-embed-wordpress aligncenter wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"5US7GEMuO4\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/is-the-wanderlust-gene-real\/\">Is the &#8220;wanderlust gene&#8221; real?<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Is the &#8220;wanderlust gene&#8221; real?&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/is-the-wanderlust-gene-real\/embed\/#?secret=jdhiiEaeVk#?secret=5US7GEMuO4\" data-secret=\"5US7GEMuO4\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><figcaption> &nbsp;When this &#8220;restless&nbsp;<em>gene<\/em>&#8221;&nbsp;DRD4-7R is present in children they are often diagnosed with Attention Deficit Hyperactivity Disorder (<em>ADHD<\/em>). <\/figcaption><\/figure>\n\n\n\n<p>Since the &#8220;Wanderlust gene&#8221; is real and ADHD has often been put into question, here is another study on what we know to be:<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>The present study investigated gender differences in the associations between the&nbsp;<em>DRD4<\/em>&nbsp;variable number tandem repeat (VNTR) polymorphism and adolescent delinquency, short temper and thrill seeking. We also explored whether the gender-specific expression of the&nbsp;<em>DRD4<\/em>&nbsp;can be explained by gender differences in the exposure to psychosocial risks, such as poor parent\u2013child relationship. Participants were 263 14- to 17-year olds (50% males) living in Russia. DNA was extracted from saliva samples and the VNTR&nbsp;<em>DRD4<\/em>&nbsp;polymorphisms were genotyped using polymerase chain reaction. Participants reported on the extent of their delinquent behaviour, short temper, thrill seeking and exposure to psychosocial risk (i.e. poor parental monitoring of adolescent behaviour, exposure to violence and peer delinquency). Compared to individuals with the 4\/4 genotype, males, but not females, with the 7-repeat allele (7R) had significantly higher delinquency, short temper and thrill seeking. This interaction effect, however, was completely explained by males\u2019 higher exposure to psychosocial risk factors. When parental monitoring of youths\u2019 activities and youth exposure to violence were included in the model, the 7R \u00d7 gender interaction was no longer significant. Thus, social context plays an important role in explaining gender-specific phenotypic expression of the&nbsp;<em>DRD4<\/em>&nbsp;gene.<br><\/p><cite>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3023085\/<\/cite><\/blockquote>\n\n\n\n<p>If you have been diagnosed, what if anything has been done about it? What advice do you have for those unable to fake interest for a long enough time not to trigger &#8220;ADHD&#8221; in the minds of those who have learned to be okay with being interested in everything and nothing?<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p> Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. Associations were found with ADHD (attention deficit hyperactivity disorder), substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. This article reviews the principle published associations of DRD4 variants with psychiatric disorders.<br><br> <\/p><cite>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3560519\/<\/cite><\/blockquote>\n\n\n\n<p><strong>ADDED:<\/strong><\/p>\n\n\n\n<p>What is now of great interest is DRD4-7R frequencies based on ABO and Rh factor. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>This article reports an association between the variation of&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/dopamine-receptor-d4\">dopamine D4 receptor<\/a>&nbsp;(DRD4)&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/allele-frequency\">allele frequencies<\/a>&nbsp;around the globe and population migration patterns in prehistoric times. After compiling existing data on DRD4 allele frequencies of 2,320 individuals from 39 populations and on the migration pattern of these groups, we found that, compared to sedentary populations, migratory populations showed a higher proportion of long alleles for DRD4. The correlation between macro-migration (long-distance group migration) and the proportion of long alleles of DRD4 was .85 (<em>p<\/em>&nbsp;&lt; .001), and that between micro-migration (sedentary vs. nomadic settlement) and the proportion of long alleles was .52 (<em>p<\/em>&nbsp;= .001). We discussed the adaptive value of long alleles of DRD4\u2014a&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/genetic-traits\">genetic trait<\/a>&nbsp;that has been linked in some studies to the&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/personality-traits\">personality trait<\/a>&nbsp;of novelty-seeking and to hyperactivity\u2014 in migratory societies and the possibility of natural selection for a migration gene.<\/p><\/blockquote>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S109051389900015X?via%3Dihub\">Population Migration and the Variation of Dopamine D4 Receptor (DRD4) Allele Frequencies Around the Globe<\/a><\/p>\n\n\n\n<p>Here are some more questions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Is the Wanderlust gene higher in countries such as USA?<\/li><li>Were the migrants throughout history higher in Rh negative blood than those who stayed behind?<\/li><\/ul>\n\n\n\n<p>More links:<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20305304\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/20305304\/<\/a><\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent child psychiatric problems with a complex genetic and environmental background. According to the prevailing view, main factors of the disorder are prefrontal dopamine deficiency and incomplete central dopaminergic functioning. Twin studies suggest substantial heritability in the background of the disease, and the studied candidate genes involve components of the dopamine system. Moreover, various noxious pre- and perinatal environmental impacts have been implicated in the pathogenesis of ADHD. Here we review experimental results from epidemiological, tissue and animal studies that assigned a causal role to fetal hypoxia in the development of ADHD and pointed out that the dopaminergic neurotransmission is sensitive to hypoxia. Allelic variants of the D4 dopamine receptor (DRD4) are well characterized risk factors of ADHD. Recently we have reported that hypoxia enhanced the promoter activity of DRD4 gene several fold. These observations suggest that the effect of hypoxia on the dopaminergic neurotransmission might be an important factor in the pathomechanism of ADHD.<br><\/p><\/blockquote>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Are rh negatives more likely to have &quot;ADHD&quot;?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Are rh negatives more likely to have &quot;ADHD&quot;?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>I have previously posted a study on it, but before I post the new one, I would like to first clarify what exactly we may understand or not understand under the term. This is not a long video as it would make no sense stretching your attention span over the topic of such. The questions that come to mind are as follows: do you tend to tune out quickly or remove yourself from situations that are not for you? do you have a strong sense regarding what you are and what you are not interested in? do those talking about low attention span also criticize spending too much time on what you might be interested in? (the accusation of obsessive <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Are rh negatives more likely to have &quot;ADHD&quot;?\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":8667,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-8655","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/09\/drd4_4-1311x800.jpg?fit=1311%2C800&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-2fB","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/8655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=8655"}],"version-history":[{"count":5,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/8655\/revisions"}],"predecessor-version":[{"id":8668,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/8655\/revisions\/8668"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media\/8667"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=8655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=8655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=8655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}