{"id":9289,"date":"2020-12-12T11:40:52","date_gmt":"2020-12-12T11:40:52","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=9289"},"modified":"2020-12-12T11:41:04","modified_gmt":"2020-12-12T11:41:04","slug":"how-your-genes-could-increase-your-risk-of-dying-from-covid","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/how-your-genes-could-increase-your-risk-of-dying-from-covid\/","title":{"rendered":"How your genes could increase your risk of dying from COVID"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How your genes could increase your risk of dying from COVID\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<p>Why some people experience no symptoms from COVID while others fall severely ill and die may be due to five genomic factors, a study has found.<br><\/p>\n\n\n\n<p>The genetic material studied came from patients in 208 intensive care units in the UK.<\/p>\n\n\n\n<p>One of the biggest mysteries of COVID-19 has been why some people experience no symptoms from the illness, while others fall severely ill and die.<\/p>\n\n\n\n<p>The answer may be in the genes, a new joint British and Australian study suggests.<\/p>\n\n\n\n<p>Researchers from the University of Queensland, Monash University and the University of Edinburgh studied the genomes of 2244 critically ill patients with COVID-19 and compared the genetic makeup of these individuals to the genomes of a control group.<\/p>\n\n\n\n<p>They found five genetic sequences more common in the critically-ill COVID group.<\/p>\n\n\n\n<p>The genes that seemed to make patients more susceptible to COVID were those involved in inflammatory processes and the body\u2019s response to invading viruses.<\/p>\n\n\n\n<p>Lead author Kenneth Baillie and colleagues said knowing which genes play a role in COVID susceptibility could help scientists figure out which existing medications may be able to treat or slow down the illness.<\/p>\n\n\n\n<p>\u201cOur findings reveal that critical illness in COVID-19 is related to at least two biological mechanisms: innate antiviral defences, which are known to be important early in disease, and host-driven inflammatory lung injury, which is a key mechanism of late, life-threatening COVID-19,\u201d he said.<\/p>\n\n\n\n<p>\u201cBoth mechanisms may be amenable to targeted treatment with existing drugs.<\/p>\n\n\n\n<p>\u201cLarge-scale randomised clinical trials will be essential before any change to clinical practice.\u201d<\/p>\n\n\n\n<p>He said many diseases were greater or less deadly depending on your genes, including the flu.<\/p>\n\n\n\n<p>\u201cSusceptibility to life-threatening infections and immune-mediated diseases are both strongly heritable,\u201d he said.<\/p>\n\n\n\n<p>\u201cIn particular, susceptibility to respiratory viruses such as influenza is heritable and known to be associated with specific genetic variants.\u201d<\/p>\n\n\n\n<p>The genes identified in the study were IFNAR2, OAS, DPP9, TYK2 and CCR2.<br><\/p>\n\n\n\n<p><em>Original article:<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.news.com.au\/lifestyle\/health\/health-problems\/how-your-genes-could-increase-your-risk-of-dying-from-covid\/news-story\/ce34d3f0ecacc605b7ba804919c87b67\">https:\/\/www.news.com.au\/lifestyle\/health\/health-problems\/how-your-genes-could-increase-your-risk-of-dying-from-covid\/news-story\/ce34d3f0ecacc605b7ba804919c87b67<\/a><\/p>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How your genes could increase your risk of dying from COVID\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How your genes could increase your risk of dying from COVID\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Why some people experience no symptoms from COVID while others fall severely ill and die may be due to five genomic factors, a study has found. The genetic material studied came from patients in 208 intensive care units in the UK. One of the biggest mysteries of COVID-19 has been why some people experience no symptoms from the illness, while others fall severely ill and die. The answer may be in the genes, a new joint British and Australian study suggests. Researchers from the University of Queensland, Monash University and the University of Edinburgh studied the genomes of 2244 critically ill patients with COVID-19 and compared the genetic makeup of these individuals to the genomes of a control group. They <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"How your genes could increase your risk of dying from COVID\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":9071,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-9289","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/11\/coronavirus-covid-19-disease-cells-infection-dangerous-microscope-look-violet-orenge-tone-violet-orenge-3d-render-illustration_125583-39.jpg?fit=626%2C352&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-2pP","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/9289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=9289"}],"version-history":[{"count":2,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/9289\/revisions"}],"predecessor-version":[{"id":9293,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/9289\/revisions\/9293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media\/9071"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=9289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=9289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=9289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}