{"id":9302,"date":"2020-12-13T10:27:28","date_gmt":"2020-12-13T10:27:28","guid":{"rendered":"https:\/\/www.rhesusnegative.net\/staynegative\/?p=9302"},"modified":"2020-12-14T10:26:17","modified_gmt":"2020-12-14T10:26:17","slug":"five-genes-often-found-in-severe-cases-of-covid-19","status":"publish","type":"post","link":"https:\/\/www.rhesusnegative.net\/staynegative\/five-genes-often-found-in-severe-cases-of-covid-19\/","title":{"rendered":"Five genes often found in severe cases of Covid-19"},"content":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Five genes often found in severe cases of Covid-19\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>\n<h3 class=\"wp-block-heading\">Revealed: the five genes&nbsp;&nbsp;<\/h3>\n\n\n\n<h2 class=\"wp-block-heading\">TYK2&nbsp;<\/h2>\n\n\n\n<p>Creates an enzyme that can lead to inflammation&nbsp;<\/p>\n\n\n\n<p>Is targeted with JAK inhibitors and one already approved for use in humans is baricitinib which treats rheumatoid arthritis&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">CCR2<\/h2>\n\n\n\n<p>Targetable by drugs that are in trials but are not widely used, for psoriasis&nbsp;<\/p>\n\n\n\n<p>Evidence for this gene is not as strong as for other genes in the study, but Dr&nbsp;Baillie says it is still \u2018compelling\u2019<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">OAS1<\/h2>\n\n\n\n<p>Is a gene that initiates a signal that activates an enzyme which degrades RNA derived from viruses.&nbsp;<\/p>\n\n\n\n<p>Several other coronavirus have a way of preventing this mechanism. No evidence yet for SARS-CoV-2, but it might be a specific feature that does this.<\/p>\n\n\n\n<p>Targettable by a&nbsp; class of drugs called&nbsp;phosphodiesterase 12 inhibitors.<\/p>\n\n\n\n<p>These are not currently in clinical trials but theoretically would enhance antiviral effect of this system.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">IFNAR2<\/h2>\n\n\n\n<p>This is a core part of signalling that is responsible to the host antiviral response.&nbsp;<\/p>\n\n\n\n<p>Signalling in this pathway is important in the chance of getting sick.&nbsp;<\/p>\n\n\n\n<p>Relevant in fighting the virus directly, much like OAS1. This is more important early in the disease as later in the disease, virus levels drops and the issue comes from the body\u2019s immune system attacking itself.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">DPP9&nbsp;<\/h2>\n\n\n\n<p>Known to play several roles in inflammation but the researchers do not yet know exactly where it fits in to the Covid-19 disease progression.&nbsp;<\/p>\n\n\n\n<p>They are therefore unable to make a direct therapeutic prediction.&nbsp;<\/p>\n\n\n\n<p>It is associated with pulmonary fibrosis and might be associated with \u2018long covid\u2019.&nbsp;&nbsp;<ins><br>\n\n<\/ins><\/p>\n\n\n\n<figure class=\"wp-block-embed-wordpress wp-block-embed is-type-wp-embed is-provider-rh-negative-blood-and-people\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"c880hf3my9\"><a href=\"https:\/\/www.rhesusnegative.net\/staynegative\/genetic-mechanisms-of-critical-illness-in-covid-19\/\">Genetic mechanisms of critical illness in Covid-19<\/a><\/blockquote><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Genetic mechanisms of critical illness in Covid-19&#8221; &#8212; The Rh Negative Blog\" src=\"https:\/\/www.rhesusnegative.net\/staynegative\/genetic-mechanisms-of-critical-illness-in-covid-19\/embed\/#?secret=sWmC0g46Vt#?secret=c880hf3my9\" data-secret=\"c880hf3my9\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><a href=\"https:\/\/healthyfrog.readsector.com\/2020\/12\/11\/five-genes-often-found-in-severe-cases-of-covid-19\/?fbclid=IwAR193rayFBDSSab54Me5t30A5Jquvz6jJZ7mWYooxqt_n4ew-gAQ601h0Dk\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"Five genes often found in severe cases of Covid-19  (opens in a new tab)\">Five genes often found in severe cases of Covid-19 <\/a><\/p>\n<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/static.hupso.com\/share\/buttons\/share-medium.png?w=640&#038;ssl=1\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Five genes often found in severe cases of Covid-19\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"excerpt":{"rendered":"<div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Five genes often found in severe cases of Covid-19\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>Revealed: the five genes&nbsp;&nbsp; TYK2&nbsp; Creates an enzyme that can lead to inflammation&nbsp; Is targeted with JAK inhibitors and one already approved for use in humans is baricitinib which treats rheumatoid arthritis&nbsp; CCR2 Targetable by drugs that are in trials but are not widely used, for psoriasis&nbsp; Evidence for this gene is not as strong as for other genes in the study, but Dr&nbsp;Baillie says it is still \u2018compelling\u2019 OAS1 Is a gene that initiates a signal that activates an enzyme which degrades RNA derived from viruses.&nbsp; Several other coronavirus have a way of preventing this mechanism. No evidence yet for SARS-CoV-2, but it might be a specific feature that does this. Targettable by a&nbsp; class of drugs called&nbsp;phosphodiesterase 12 <div style=\"padding-bottom:20px; padding-top:10px;\" class=\"hupso-share-buttons\"><!-- Hupso Share Buttons - https:\/\/www.hupso.com\/share\/ --><a class=\"hupso_toolbar\" href=\"https:\/\/www.hupso.com\/share\/\"><img src=\"https:\/\/static.hupso.com\/share\/buttons\/share-medium.png\" style=\"border:0px; padding-top:5px; float:left;\" alt=\"Share Button\"\/><\/a><script type=\"text\/javascript\">var hupso_services_t=new Array(\"Twitter\",\"Facebook\",\"Pinterest\",\"Linkedin\");var hupso_background_t=\"#EAF4FF\";var hupso_border_t=\"#66CCFF\";var hupso_toolbar_size_t=\"medium\";var hupso_twitter_via = \"datebytype\";var hupso_image_folder_url = \"\";var hupso_twitter_via=\"datebytype\";var hupso_url_t=\"\";var hupso_title_t=\"Five genes often found in severe cases of Covid-19\";<\/script><script type=\"text\/javascript\" src=\"https:\/\/static.hupso.com\/share\/js\/share_toolbar.js\"><\/script><!-- Hupso Share Buttons --><\/div>","protected":false},"author":1,"featured_media":9305,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"amp_status":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-9302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-facts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.rhesusnegative.net\/staynegative\/wp-content\/uploads\/2020\/12\/36733016-9043703-image-a-8_1607702065103.jpg?fit=634%2C422&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5DV68-2q2","_links":{"self":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/9302","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/comments?post=9302"}],"version-history":[{"count":3,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/9302\/revisions"}],"predecessor-version":[{"id":9320,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/posts\/9302\/revisions\/9320"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media\/9305"}],"wp:attachment":[{"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/media?parent=9302"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/categories?post=9302"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rhesusnegative.net\/staynegative\/wp-json\/wp\/v2\/tags?post=9302"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}