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ABO/Rh Blood Groups and COVID-19: Temporal Analyses Point Out Rh-negative with the Greatest Correlations

ABO/Rh Blood Groups and COVID-19: Temporal Analyses Point Out Rh-negative with the Greatest Correlations

 Rhesusnegative.net2
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The following study has been brought to my attention by Paul:

ABO/Rh Blood Groups and COVID-19: Temporal Analyses Point Out Rh-negative with the Greatest Correlations
Click the image to access the full study’s PDF file directly

It has yet to be peer-reviewed, yet the results show promising similarities to those from previous studies, though there is an expanding roam of data created which will likely lead to many more studies worldwide.

Abstract:

In this work, the correlations between ABO/Rh blood groups and the number of deaths from COVID-19 were studied through Pearson’s correlation coefficients, while considering the distribution of blood groups in populations of 88 countries for a period of 166 days and the daily cumulative deaths since the fifth death. The current study stems from the need to understand associations between ABO/Rh blood groups and COVID-19 in a temporal analysis. The preliminary results indicated that correlations change statistically as the pandemic extends and the time of exposure to the SARS-CoV-2 increases. A strong maximum correlation was obtained for blood groups A, O, A-, O-, Rh- and blood group A correlations were higher than those of the O blood group during most of the study period. Correlations of the blood type Rh-negative remained greater than those of the blood type Rh-positive throughout the 166-day period. With these studies it was possible to interpret the temporal evolution of the pandemic from the perspective of the correlation coefficients, here modeled by degree 11 polynomials using the least squares method. In addition, the behavior of the temporal evolutions of the correlations suggested studies on the total number of daily deaths, so rates of establishment of the pandemic COVID-19 and characterization parameters were proposed.

A part of the highlights regarding Rh negative blood:

The relationship found between the Rh blood groups (Rh+ and Rh-) with the greatest correlations in the temporal Analyses 1-3 of the blood type Rh- suggests the need to proceed with studies in this direction. Clinical/Epidemiological studies have often failed to detect these relationships yet, possibly due to the following factors: scarce data for the blood type Rh-, approaches for short and geographically localized periods, but recent studies have already begun to draw attention to this approach.

Based on studies showing that blood type Rh-negative has a certain protection against viral attacks Flegr[15], the greatest correlations obtained here could suggest an important role of Rh-negative blood type in a broader scope of the virus spread.

The study had been written Feb. 21, 2021, posted March 11, 2021 and last been revised March 20, 2021.

See also:

Clarifications: COVID-19 and Rh negative blood types
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Rhesusnegative.net

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2 Comments

  1. Richard Youatt March 31, 2021

    See also :

    https://www.acpjournals.org/doi/10.7326/M20-4511?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&

    Results:
    A total of 225 556 persons were included, with a mean age of 54 years. The aRR of SARS-CoV-2 infection for O blood group versus A, AB, and B blood groups together was 0.88 (95% CI, 0.84 to 0.92; ARD, −3.9 per 1000 [CI, −5.4 to −2.5]). Rhesus-negative (Rh−) blood type was protective against SARS-CoV-2 infection (aRR, 0.79 [CI, 0.73 to 0.85]; ARD, −6.8 per 1000 [CI, −8.9 to −4.7]), especially for those who were O-negative (O−) (aRR, 0.74 [CI, 0.66 to 0.83]; ARD, −8.2 per 1000 [CI, −10.8 to −5.3]). There was also a lower risk for severe COVID-19 illness or death associated with type O blood group versus all others (aRR, 0.87 [CI, 0.78 to 0.97]; ARD, −0.8 per 1000 [CI, −1.4 to −0.2]) and with Rh− versus Rh-positive (aRR, 0.82 [CI, 0.68 to 0.96]; ARD, −1.1 per 1000 [CI, −2.0 to −0.2]).

  2. Lesley April 3, 2021

    I really hope doctors start studying this more

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