Here is the revised version from July 21st, 2020 of a study I have recently posted. Thank you to Paul for sharing it in a comment here. Here are some highlights regarding Rh negative blood and COVID-19 alongside brief comments of mine:
Using observational data on 7,770 SARS-CoV-2-tested individuals at New York Presbyterian (NYP) hospital, we find evidence of overall association with ABO blood groups and a beneficial association between Rh-negative blood groups and both infection status and death.
I am happy to see that in this version, the obvious is being focused on which didn’t happen in the previous one.
Finally, we show that blood type’s effects are not explained by other risk factors (age, sex, race, ethnicity, hypertension, diabetes mellitus, obesity, and cardiovascular and respiratory diseases). To our knowledge, this is the first report of an independent Rh(D) association with COVID-19.
This is what I have been waiting for.
Since there were few AB-negative individuals tested for SARS-CoV-2 infection, we excluded AB-negative from all ABO/Rh analyses.
Also, great move. Sure enough, the initial version prompted some people to assume that AB negatives were immune which couldn’t be further from the truth.
While Rh(D) information was not available from the other meta-analysis sites, we found consistent evidence for protective associations between Rh negative blood groups and SARS-CoV-2 infection and death in NYP/CUIMC data. Negative Rh blood groups are less common, representing only 9% of individuals in our data, and Rh group associations were consistently moderated by adjustment for covariates (Figure 1), suggesting the potential for confounding due to population stratification or selection bias. Further work is needed to better understand the associations between Rh(D) blood groups and COVID-19.
This particular part I have made several posts and videos about and I am happy they spell it out. Hopefully, more studies will arise and in light of the situation we are in, more efforts will be made to determine the nature of how Rh negatives might enjoy some form of protective associations.
Here are more of my personal comments and why this revision is so significant to me:
This was my post when the first edition came out:
This newer study appears to confirm what’s been indicated about blood type O and Rh negative blood groups:
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I had one more thought to the D protein and that is women negative blood type women. If she ever gets exposed to the positive blood if carrying a positive blood type baby I would think she would then be hyper reactive to any exposure to anything
associated with the D protein and her body would recognize it at a threat thus react to kill it unlike negative men who
would not have had such an exposure since there is no intermingling of blood during procreation. I would think the negative males would be more susceptible to the exposure to any pathogens associated to the D protein in the testing of such in the Rhesus monkeys. Just a thought. Comments welcome.
In Uk when I had my Son’s they awaited for Blue babies. I am now 73 and hyper allergic to everything. I do experience some form of ESP. Cheers Mate
Hello, you didn’t mention your blood type or your wife’s. I don’t like to assume things. If you are negative I can understand being over sensitive to a lot of stuff however you have not been exposed to positive blood like a woman being a negative carrying a positive baby or a positive woman carrying a negative blood type wherein each scenario would result in the intermingling of the blood at birth. Each can get away with one baby’s birth but each subsequent pregnancy would require the RhoGam shot in order to carry to term. Now I did meet years ago a young woman who was negative and her husband was a positive. She had extreme difficulty with the first three pregnancies. She at the forth pregnancy she changed her diet and was adding Barleylife made by AIM corporation. She had, had the RhoGam shot twice and told she would need it at every subsequent pregnancy. She told me she didn’t have the shot when the fourth baby was born and there was no problems. She did not say what the babies blood type was, it could have been a negative, wherein there would be no problems. I ran into her years later and at that time she was pregnant with number 8. Now that I know about this personally I would love to talk with her but I have lost touch. I find this very interesting.
Gwen is a woman….
Hello I am mother of 7. I too am the negative. I delivered six children and lost one . All csections . I have had rhogam with each pregnancy. My children range 3-20 years in age . I was searching for help and information. Can anyone help me here?
Are you saying women who had the RhoGam shot may be hyper reactive and allergies? Just wondering, I am so allergic to everything and had 2 shots as a RH- woman. I and family members who are women also have this problem.
I was also wondering about Covid-19 and RH- people, I don’t know anyone that’s RH- who has gotten that virus. Is there any news on this subject, other than that posted here?
Thank you
i’m using this copy of this preprint article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276013/
“Using observational data on 7,770 SARS-CoV-2-tested individuals at New York Presbyterian (NYP) hospital” … “We determined blood groups for SARS-CoV-2-tested individuals using laboratory measurements recorded in the NYP/CUIMC EHR system. Excluding individuals with contradictory blood group measurements, we found 7,770 individuals (Table 1) with known blood groups who received a SARS-CoV-2 swab test (either positive or negative result).” link to the main graph being discussed is here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276013/table
“Our meta-analysis found evidence for a protective association between O blood groups and SARS-CoV-2 infection, consistent with a similar association discovered for SARS-CoV-14. Guillon et al. provide evidence suggesting human anti-A antibodies may interfere with interactions between the SARS-CoV-1 spike protein and the human ACE2 receptor14. Since anti-A antibodies are present in individuals with both B and O blood groups, this result suggests that B and O blood groups could be at lower risk. ”
“…we found consistent evidence for protective associations between Rh negative blood groups and SARS-CoV-2 infection and death in NYP/CUIMC data. Negative Rh blood groups are less common, representing only 9% of individuals in our data…”
“Our data are preliminary, and we will be better able to assess the relationship between blood group and intubation or death when more patients become tested, intubated, and recovered.”
“Conclusion
In this study we found evidence for association between ABO and Rh blood groups and COVID-19. Using data from NYP/CUIMC, the UK Biobank, and previously-reported data from China, we found evidence for enrichment of B and depletion of O blood groups among SARS-CoV-2 positive patients. Rh(D) positive blood types were associated with both SARS-CoV-2 infection and death following infection. We demonstrated that the associations we found were not explained by confounding due to demographics or several known risk factors. Our results add further evidence to the previously-discovered COVID-19 protective association for O blood type, and we show evidence for additional associations between B and Rh(D) blood groups.”
supplementary information tables link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276013/bin/NIHPP2020.04.08.20058073-supplement-1.pdf
– my comments: –
from supplementary table 1 it shows that O negs had the highest median age of the negs except the AB’s, so they were generally older than A negs & B negs (there were 27 AB negs in the study from NYC which just considered those who came to this hospital and were tested for CVD19…data from China & the UK were used in some other table & graphs)…for some reason only ~ 40% of the people listed in supplementary table 1 were recorded as male…between 44.2% (B neg) & 59.3% (AB neg) was the range for those who were Rh(D) neg and claimed to be white, so roughly slightly more than 50% claim to be non-white or other in the Rh(D) neg group from this NYC hospital [i wonder how the CCR5-delta32 gene deletion/mutation affects the Rh(D) neg data and specifically those claiming to be white & their outcome, given the historical overlap in genealogical geography between being Rh(D) & having 1 or 2 copies of CCR5-delta32? maybe it would lower the # percentage-wise for whites who test positive for CVD19 as a starting point – for those having 1 copy and 2 copies…it would be nice if there was an easy test to determine who has this mutation and then see/study/look at/follow the results/what happens…this might make some who have it partially or from both parents feel more better/less stressed]…around 50% of all blood types had hypertension…about 70% of all blood types had cardiovascular disease…around 30% had diabetes mellitus…about 40% were obese…excluding the AB negs – in this hospital A negs had slightly lower CVD19 positive test results percentages than B negs & O negs, while doing noticeably better with % intubated & died vs B negs & O negs…the intubation and death rates for Rh(D) negs vs Rh(D) positives can sometimes be over 50% less, w/ Rh(D) negs in this study doing best (age, health & ethnicity may have contributed to these results).
fwiw: from a New York Times article::
Q&A
By C. Claiborne Ray
Nov. 26, 1996
See the article in its original context from November 26, 1996, Section C, Page 7
https://www.nytimes.com/1996/11/26/science/q-a-466999.html
“In the familiar A-B-AB-O system, the New York Blood Center estimates that out of 100 people in the general population, 45 percent will be group O, with 39 of them Rh positive and 6 Rh negative; 40 percent will be group A, with 35 of them Rh positive and 5 Rh negative; 10 percent will be group B, with 8 Rh positive and 2 Rh negative, and 5 percent will be group AB, with 4 Rh positive and 1 Rh negative.”
so, if this Dr.’s estimate for blood type and it’s % in the general population applies to New York City & this hospital, then adding up the Rh(D) negs #’s i get 14 which would mean Rh(D) negs represent ~ 14% of the total ABO blood group. using the data from Supplementary Table 1: Cohort breakdown by ABO/Rh blood group: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276013/bin/NIHPP2020.04.08.20058073-supplement-1.pdf … there are 2206 total positive cases, from which 157 are Rh(D) negs…this means that ~ 7.11% of those tested & positive are Rh(D) negs vs a gen. pop. # of 14%…which could mean Rh(D) are about 50% less likely to test positive for CVD19 in general. the % Rh(D) negs intubated was ~ 4.93% (29 out or 588) out of the total intubated. out the 505 who died, 21 were Rh(D) negative and this is ~ 4.16% of the total 505. so overall, Rh(D) negs definitely seem less likely to catch CVD19 and much less likely to have the worst outcomes when compared w/ Rh(D) positives and their percentages in the general population as a whole.
With any luck, this well conducted , but limited, study may be a significant turning point for getting more research and focus of attention on the relationship between Rh Neg and immunity (or lack of it) to various diseases.
I wonder if there is any chance of getting the attention of any of the many labs and Universities that are doing the research/testing on possible COVID19 vaccines?
I have seen the power/effectiveness of combined lab research and clinical research in the 5 years that I worked in such an environment.
Hi Richard, we have been on different topics. Hope your well. So question I asked months ago! What lab? Here we have many rhesus negatives..pathetic how few hospital data based on!!! Let’s ask Mike to have address of lab…and subject it to all strains to get an answer…we are here…Mike please post a lab address…let’s figure out…what is truth…we know of two strains…for our well being…have to send blood tests somewhere! Want to do research? Let’s do it!!!!
I’m very concerned about the vaccine and how we will react to it. Will our overactive immune systems, over react and cause an allergic reaction??
My niece is Rh negative and allergic to everything- and so am I. I react to anti biotics- not a anaphylactic reaction but they mess me up- I break out all over. No breathing issues-
I sure hope they do some studies on us before including us in massive generic vaccine programs.
fwiw, i’m not planning on taking/accepting any shots or anything besides my own chosen supplements & the like/similar things – (multi-vitamins: vitamin D seems to be very important…many w/ severe symptoms seems to have low readings – for whites: vite D supplementation would important especially if one’s not getting much direct sunlight on one’s skin during the Winter months…vite C seems to be important too as is zinc…the following look helpful prophylactically and if mild symptoms occur: hesperidin, elderberry sambucus syrup, low dose aspirin to help deal w/ CVD19’s clotting issues…and so on). i like Cold-Eeze’s w/ zinc plus Defense lozenges best. i have quercetin & NAC supplements also…and others in case i think i need them. i prepared well and bought all of these things & more before i got the impression i might be highly resistant to CVD19 during the past month (multi-vites i always have and take regardless…i chew them)…i never got a scar/a “take” from a smallpox shot i got when i was ~ 6 (in 1969). that i believe means i’m homozygous for the CCR5-delta32 gene deletion mutation, which may make me quite resistant to CVD19 by itself and i should get some more help being O neg as well. — i’m not a Doctor: this is just what i do & think for myself … each should do their own research & decide what’s best for yourself individually. —
– looks like some tests for CCR5-delta32 do exist: https://www.delta-32.com/ccr5-delta32.html … for some reason i never noticed this before. i guess i was too interested in just understanding things initially. some say 23andme.com can test for it also. i’m not sure. looks like it costs ~ $200 at the link above.
Ken
I have no intention of ever taking either the “jab” or any “test” (the most common “test” for “cov&% 19” has an estimated 97% false positive rate) and because of the all the so-called data on this disease is totally false. BTW I’m a retired epidemiologist with 30 yrs experience analyzing health data including 14 yrs analyzing death data and 3 yrs experience doing influenza surveillance.
I am also Rh negative and suspect I may have the CCR5-delta 32 gene because I never got a “take” (i.e., no scar) from any of the many(!) smallpox vaccines I was required to take as a child. Probably not going to bother doing the test for it though; too expensive. However, all 4 of my brothers also never got a scar from the smallpox vaccines (although I know my mother had a scar – not sure about my father). At the time we were required to show our “scar” to the school nurse to get in… since we never had scarring every year they made us go back and get note from the doctor about it… I absolutely remember him redoing the vaccine on us every year, although I got my original immunization record and he only documented me as having a smallpox vaccine about 4-5 of those years.
~Jean
I am located in Australia and have been noticing main stream news articles slowly being released to the general public relating to blood type associations and Covid-19.
Though the below article does not mention the RH factor (mainly O group), it does suggest studies are being considered relating unknown “binding” protective factors relating to blood type and covid-19.
https://www.news.com.au/world/coronavirus/australia/coronavirus-australia-live-victoria-qld-nsw-covid19-updates/live-coverage/131391925b1af68284b089e7f1e7a280
I would be interested to know what medrxiv study the above article is referring to, if it’s the latest study presented on this web page, IMO the above study clearly states an apparent RH protective factor relating to Covid-19.
Could this be the beginning of what you have been observing in your studies relating to the RH factor protective properties slowly reaching the main stream media?
On another note in relation to the vaccine, there is now talk in Australia of the vaccine being delivered via a nasal spray and not intravenously. If this is the case, I would presume the nasal vaccine would also need to bind to the same receptors as the virus, perhaps a nasal vaccine would also not effect those with “protective factors” and simply pass through the body?
This vaccine theory is something I have been considering for quite some time, for some reason my intuitive mind keeps nudging me to look deeper.
Thank you, Paul, for your thoughts on the receptors and vaccinations. My husband is totally immune to chicken pox. Because he never caught it as a child though he was exposed and then he was exposed again with our children he was recommended the varicella vaccine. He received it twice and still never developed a titer. But the new vaccines don’t actually deliver the virus to the body for a response. They work completely different. I don’t understand how they work completely but it doesn’t sound like it will be using receptors but rather a coding of sorts and our messenger RNA to send a code to the outer part of our DNA to start producing a protein. Which apparently is completely different from any previous vaccine or medicine we have ever had in the past. I will look into what you mentioned though. Very good food for thought.