Rh factor is associated with individual radiosensitivity: A cytogenetic study

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The present study suggested that chromosomal radiosensitivity of lymphocytes in normal individuals with Rh+ factor is higher than their Rh counterparts. However, this difference is not generalized to other types of cells. This finding revealed that the Rh factor can be considered one of the hereditary traits affecting individuals’ radiosensitivity and can be a valuable item in radiation protection regulations. However, further in-vivo and in-vitro studies are needed for validation.

In this experimental study, informed consent was acquired from 50 healthy human volunteers (25 Rh+ and 25 Rh−) in the A blood group who ranged in age from 22 to 23 years old.

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All responders completed a questionnaire to provide information on their lifestyle and exposure to chemical and physical agents. Having a history of known irradiation, smoking, drug treatment, and alcohol consumption were exclusion criteria. Blood samples were taken from responders under sterile conditions using heparinized syringes. Finally, samples were divided into two separate groups (control and exposed blood samples). All of them were transferred in cold environmental conditions.

Rh factor is associated with individual radiosensitivity: A cytogenetic study

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