The Rh Negative Blog

What is Rh null vs Rh negative?

Magnification on a group of red blood cells in blood plasma

There are more than 50 antigens known to exist within the Rh blood group system.

One of those antigens is the D antigen.

When the D antigen is lacking, you are Rh- negative, also often written as Rh- or Rh(D) negative.

When all of the antigens of the Rh blood group system are missing, you are Rh null.

Rhnull phenotype is a rare blood group with a frequency of approximately 1 in 6 million individuals, transmitted via an autosomal recessive mode. It is characterized by the weak (Rhmod) or lack (Rhnull) of expression of all Rh antigens on the red cells.